The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation

Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure. As antiviral target, NS1-RNA-binding domain (RBD) remains unexplored, despite its critical role in replicatio...

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Autores principales:	Luis André Santos, João Trigueiro-Louro, Helena Rebelo-de-Andrade
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-02-01
Colección:	Viruses
Materias:	influenza A virus antiviral target druggable pockets mutagenesis viral replication viral fitness
Acceso en línea:	https://www.mdpi.com/1999-4915/18/3/279
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