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Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and function of LBs remains enigmatic. We found th...

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Principais autores: Florian Ingo Schmidt, Christopher Karl Ernst Bleck, Lucia Reh, Karel Novy, Bernd Wollscheid, Ari Helenius, Henning Stahlberg, Jason Mercer
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2013-08-01
Series:Cell Reports
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124713003203
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