RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Abstract TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, a genome‐wide CRISPR/Cas9‐based screening of primary...

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Autori principali:	Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-12-01
Serie:	Advanced Science
Soggetti:	hepatocellular carcinoma RELA TP53R249S tumor suppressor Wnt/β‐catenin
Accesso online:	https://doi.org/10.1002/advs.202500335
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