Biological Effects of HDAC Inhibitors Vary with Zinc Binding Group: Differential Effects on Zinc Bioavailability, ROS Production, and R175H p53 Mutant Protein Reactivation

The coordination of zinc by histone deacetylase inhibitors (HDACi), altering the bioavailability of zinc to histone deacetylases (HDACs), is key to HDAC enzyme inhibition. However, the ability of zinc binding groups (ZBGs) to alter intracellular free Zn⁺² levels, which may have far-reachi...

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Autori principali:	Brianna M. Flores, Chandana K. Uppalapati, Agnes S. Pascual, Alan Vong, Margaux A. Baatz, Alisha M. Harrison, Kathryn J. Leyva, Elizabeth E. Hull
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-10-01
Serie:	Biomolecules
Soggetti:	HDAC inhibitors zinc bioavailability p53 reactivation R175H mutant p53 ROS production
Accesso online:	https://www.mdpi.com/2218-273X/13/11/1588
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