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A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction

Abnormal accumulation of alpha-synuclein (α-syn) is a central pathologic hallmark of synucleinopathies such as Parkinson’s disease (PD), with rapid eye movement sleep behavior disorder (RBD) widely recognized as a prodromal manifestation of these disorders. Although several mouse models recapitulate...

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Principais autores: Shinnosuke Yasugaki, Ami Kaneko, Hibiki Okamura, Hideki Hayakawa, Kensuke Ikenaka, Cesar Aguirre, Masashi Yanagisawa, Hideki Mochizuki, Kousuke Baba, Yu Hayashi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-03-01
Serier:Neuroscience Research
Fag:
REM sleep
pons
sublaterodorsal tegmentum
G51D alpha-synuclein
REM sleep behavior disorder
Parkinson’s disease
Online adgang:http://www.sciencedirect.com/science/article/pii/S0168010226000106
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