EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similari...

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Detalhes bibliográficos

Principais autores:	Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-02-01
coleção:	Exploration
Assuntos:	ADPKD EGR1 cyst development condensate phase separation
Acesso em linha:	https://doi.org/10.1002/EXP.20240285
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