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EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similari...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2026-02-01
Rangatū:Exploration
Ngā marau:
ADPKD
EGR1
cyst development
condensate
phase separation
Urunga tuihono:https://doi.org/10.1002/EXP.20240285
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