Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously

Abstract Background Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumor cells utilize dual mechanisms to evade macrophag...

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Ngā kaituhi matua:	Wen Luo, Hai Hoang, Katherine E. Miller, Hongwen Zhu, Serena Xu, Xiaokui Mo, Elizabeth A. R. Garfinkle, Heather Costello, Saranga Wijeratne, Wiebke Chemnitz, Ronan Gandhi, Yanling Liao, Janet Ayello, Aliza Gardenswartz, Jeremy M. Rosenblum, Kevin A. Cassady, Elaine R. Mardis, Dean A. Lee, Timothy P. Cripe, Mitchell S. Cairo
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2024-07-01
Rangatū:	Journal of Experimental & Clinical Cancer Research
Ngā marau:	CD47 blockade Chemotherapy Macrophages Ewing sarcoma
Urunga tuihono:	https://doi.org/10.1186/s13046-024-03093-w
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!