Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Abstract Sleep alterations are known to occur in Alzheimer’s disease (AD), before cognitive symptoms become apparent, and are thought to play an important role in the pathophysiology of AD. However, knowledge on the extent of macro- and microstructural changes of sleep during early, presymptomatic s...

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Hlavní autoři:	Monica van den Berg, Loran Heymans, Daniëlle Toen, Mohit A. Adhikari, Johan Van Audekerke, Marlies Verschuuren, Isabel Pintelon, Winnok H. De Vos, Annemie Van der Linden, Marleen Verhoye, Georgios A. Keliris
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-05-01
Edice:	Acta Neuropathologica Communications
Témata:	Hippocampal local field potentials REM sleep NREM sleep Sharp wave-ripples Phase-amplitude coupling TgF344-AD
On-line přístup:	https://doi.org/10.1186/s40478-025-02016-w
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