Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer’s disease transgenic and wildtype rats

Abstract Background Alterations in amine metabolism have been implicated in Alzheimer’s disease (AD), but the relationships between plasma and cerebrospinal fluid (CSF) amine levels remain insufficiently understood. Aim To investigate longitudinal changes in amines in plasma and CSF, as well as thei...

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Hauptverfasser:	Chunyuan Yin, Imke Nelen, Amy Harms, Robin Hartman, Sabine Bos, Charlotte Nijgh-van Kooij, Thomas Hankemeier, Alida Kindt, Elizabeth de Lange
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-05-01
Schriftenreihe:	Fluids and Barriers of the CNS
Schlagworte:	Alzheimer’s disease Metabolomics Amines TgF344-AD transgenic rat model CSF Plasma
Online-Zugang:	https://doi.org/10.1186/s12987-026-00811-8
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