Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity

Abstract Background In vitro blood–brain barrier (BBB) models using human induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been developed to predict the BBB permeability of drug candidates. For the differentiation of iBMELCs, Matrigel, which is a...

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Váldodahkkit:	Hiromasa Aoki, Misaki Yamashita, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2020-03-01
Ráidu:	Fluids and Barriers of the CNS
Fáttát:	Human induced pluripotent stem cell Brain microvascular endothelial cell Laminin 221 Differentiation Blood–brain barrier
Liŋkkat:	http://link.springer.com/article/10.1186/s12987-020-00186-4
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