Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells

Abstract Background The blood–brain barrier (BBB) plays an important role as a biological barrier by regulating molecular transport between circulating blood and the brain parenchyma. In drug development, the accurate evaluation of BBB permeability is essential to predict not only the efficacy but a...

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Principais autores:	Misaki Yamashita, Hiromasa Aoki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-05-01
coleção:	Fluids and Barriers of the CNS
Assuntos:	Blood–brain barrier Cell differentiation Endothelial cells Induced pluripotent stem cells Transforming growth factor beta
Acesso em linha:	http://link.springer.com/article/10.1186/s12987-020-00197-1
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