c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(-)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κ...

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Principais autores:	George Grigoriadis, Ajithkumar Vasanthakumar, Ashish Banerjee, Raelene Grumont, Sarah Overall, Paul Gleeson, Frances Shannon, Steve Gerondakis
格式:	Artigo
语言:	Inglês
出版:	Public Library of Science (PLoS) 2011-01-01
丛编:	PLoS ONE
在线阅读:	http://europepmc.org/articles/PMC3204987?pdf=render
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