c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(-)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κ...

Descrizione completa

Dettagli Bibliografici

Autori principali:	George Grigoriadis, Ajithkumar Vasanthakumar, Ashish Banerjee, Raelene Grumont, Sarah Overall, Paul Gleeson, Frances Shannon, Steve Gerondakis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2011-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC3204987?pdf=render
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!