iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

Abstract Background Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotolerance. However, some reports have claimed recently that aberrant gene...

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Xehetasun bibliografikoak

Egile Nagusiak:	Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2023-04-01
Saila:	Stem Cell Research & Therapy
Gaiak:	Autologous iPSCs NK-cells Differentiation HLA-I Beta-2-microglobulin Immunogenicity
Sarrera elektronikoa:	https://doi.org/10.1186/s13287-023-03308-5
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