Second-generation lectin microarray for high throughput glycan profiling of therapeutic antibodies

Abstract N-linked glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs), influencing efficacy, safety, and pharmacokinetics. Accurate and high-throughput glycan profiling is therefore critical for product quality and manufacturing consistency. Here, we evaluated a...

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Principais autores:	Kayla Hess, Helena Yun, Shen Luo, Uriel Ortega-Rodriguez, Grace Henry Lunde, Sarah Rogstad, Lai-Xi Wang, Baolin Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	SpringerOpen 2026-06-01
Serija:	AAPS Open
Teme:	Monoclonal antibody Glycan profile Lectin microarray High throughput Mass spectrometry Method verification
Online dostop:	https://doi.org/10.1186/s41120-026-00172-4
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