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Second-generation lectin microarray for high throughput glycan profiling of therapeutic antibodies

Abstract N-linked glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs), influencing efficacy, safety, and pharmacokinetics. Accurate and high-throughput glycan profiling is therefore critical for product quality and manufacturing consistency. Here, we evaluated a...

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Kaydedildi:
Asıl Yazarlar: Kayla Hess, Helena Yun, Shen Luo, Uriel Ortega-Rodriguez, Grace Henry Lunde, Sarah Rogstad, Lai-Xi Wang, Baolin Zhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: SpringerOpen 2026-06-01
Seri Bilgileri:AAPS Open
Konular:
Monoclonal antibody
Glycan profile
Lectin microarray
High throughput
Mass spectrometry
Method verification
Online Erişim:https://doi.org/10.1186/s41120-026-00172-4
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