Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues

Abstract Background Numerous studies suggest that abnormal upregulation of the complement cascade, a key component of the innate immune system, is involved in the pathogenesis of Alzheimer’s disease (AD), also contributing to synapse elimination in the brain. Several pieces of evidence suggest that...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Mariya Timotey Miteva, Virginia Protto, Francesco Zanzi, Francesco Pastore, Chiara Simone, Cristian Ripoli, Maria Elena Marcocci, Roberto Piacentini, Claudio Grassi, Anna Teresa Palamara, Giovanna De Chiara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Cell Communication and Signaling
Assuntos:	HSV-1 HHV-1 Herpes simplex virus Complement proteins Microglial synaptic pruning Alzheimer’s disease
Acesso em linha:	https://doi.org/10.1186/s12964-026-02745-y
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!