Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues

Abstract Background Numerous studies suggest that abnormal upregulation of the complement cascade, a key component of the innate immune system, is involved in the pathogenesis of Alzheimer’s disease (AD), also contributing to synapse elimination in the brain. Several pieces of evidence suggest that...

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Autors principals:	Mariya Timotey Miteva, Virginia Protto, Francesco Zanzi, Francesco Pastore, Chiara Simone, Cristian Ripoli, Maria Elena Marcocci, Roberto Piacentini, Claudio Grassi, Anna Teresa Palamara, Giovanna De Chiara
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Cell Communication and Signaling
Matèries:	HSV-1 HHV-1 Herpes simplex virus Complement proteins Microglial synaptic pruning Alzheimer’s disease
Accés en línia:	https://doi.org/10.1186/s12964-026-02745-y
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