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Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia

Doxorubicin (Dox) is a cornerstone in the treatment of pediatric acute lymphoblastic leukemia (ALL), but its use is limited by dose-dependent cardiotoxicity. Oxidative stress, arising from mitochondrial dysfunction, enzymatic generation of reactive oxygen species, and cardiotoxic metabolites, has be...

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Principais autores: Jesús Alonso Gándara-Mireles, Elio Aarón Reyes Espinoza, Verónica Loera-Castañeda, Lourdes Patricia Córdova Hurtado, Antonio Emilio González Font, Julio Cesar Grijalva Ávila, Ignacio Villanueva Fierro, Ismael Lares-Asseff, Cynthia Mora Muñoz, Gabriela Velasco Villa, Hugo Payán Gándara, Leslie Patrón-Romero, Horacio Almanza-Reyes
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-06-01
coleção:Current Issues in Molecular Biology
Assuntos:
doxorubicin
cardiotoxicity
oxidative stress
8-OHdG
pharmacogenetics
acute lymphoblastic leukemia
Acesso em linha:https://www.mdpi.com/1467-3045/48/6/577
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