Exposure-response relationship of sertraline in pediatric patients with anxiety disorders: a population pharmacokinetic analysis

BackgroundSertraline is widely used for the treatment of anxiety disorders in pediatric populations; however, substantial interindividual pharmacokinetic (PK) variability may significantly influence therapeutic efficacy and the occurrence of adverse events (AEs).ObjectiveTo characterize the populati...

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Автори:	Jesus Alonso Gandara Mireles, Julio Cesar Grijalva Avila, Ignacio Villanueva Fierro, Cynthia Mora Muñoz, Pedro Sanchez Campos, Sagrario Salas Name, Maura Antonia Lazcano Franco, Adrián Arceo Durán, Karla Patricia Rosales Silva, Hugo Ontiveros Sánchez, Maria Guadalupe Nieto Pescador, Odín Romero Soto, Verónica Loera Castañeda, Leslie Patrón Romero, Horacio Almanza Reyes
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2026-06-01
Серія:	Frontiers in Pharmacology
Предмети:	adverse events anxiety pediatrics pharmacokinetics/pharmacodynamics sertraline
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1862275/full
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Exposure-response relationship of sertraline in pediatric patients with anxiety disorders: a population pharmacokinetic analysis

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