Position Weight Matrix or Acyclic Probabilistic Finite Automaton: Which model to use? A decision rule inferred for the prediction of transcription factor binding sites

Abstract Prediction of transcription factor binding sites (TFBS) is an example of application of Bioinformatics where DNA molecules are represented as sequences of A, C, G and T symbols. The most used model in this problem is Position Weight Matrix (PWM). Notwithstanding the advantage of being simpl...

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Principais autores:	Guilherme Miura Lavezzo, Marcelo de Souza Lauretto, Luiz Paulo Moura Andrioli, Ariane Machado-Lima
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Sociedade Brasileira de Genética 2024-01-01
Colecção:	Genetics and Molecular Biology
Assuntos:	Transcription factor binding site position weight matrix ChIP-seq position dependency model comparison
Acesso em linha:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000700802&tlng=en
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