Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics

ObjectiveEpilepsy is a complex disorder with growing evidence linking gut microbiota and metabolism, though causal relationships unclear. This study investigated causal effects of gut microbiota on three epilepsy types via metabolic pathways, using Mediation Mendelian randomization (MR), evaluated d...

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Hlavní autoři:	Jiayin Gong, Mingxing Lin, Lizhen Chen, Wenting Xiong, Yuying Zhang, Changyun Liu, Shenggen Chen, Wanhui Lin, Chaofeng Zhu, Huapin Huang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Microbiology
Témata:	gut microbiota epilepsy mediation Mendelian randomization metabolomics sphingomyelin medium-chain triglyceride diet
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1662050/full
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