Microbiota–sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics

ObjectiveEpilepsy is a complex disorder with growing evidence linking gut microbiota and metabolism, though causal relationships unclear. This study investigated causal effects of gut microbiota on three epilepsy types via metabolic pathways, using Mediation Mendelian randomization (MR), evaluated d...

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Autors principals:	Jiayin Gong, Mingxing Lin, Lizhen Chen, Wenting Xiong, Yuying Zhang, Changyun Liu, Shenggen Chen, Wanhui Lin, Chaofeng Zhu, Huapin Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-11-01
Col·lecció:	Frontiers in Microbiology
Matèries:	gut microbiota epilepsy mediation Mendelian randomization metabolomics sphingomyelin medium-chain triglyceride diet
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1662050/full
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