High affinity is insufficient for strong B cell activation by HIV broadly neutralising antibodies

Abstract HIV broadly neutralizing antibodies (bnAbs) have been widely studied, and inducing a robust broadly neutralizing response remains a goal for many human vaccine studies. Much research focusses on creating higher affinity antigens to target bnAb precursors, however this ignores the role of no...

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Autori principali:	Chloe Rees-Spear, Olivia Payne, Emma Touizer, Alan Kennedy, Luke Muir, Peter Thomas, Alyssa Thomas DeCruz, Rachel A. McKendry, Leo Swadling, Marit J. van Gils, James E. Voss, Laura E. McCoy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	npj Vaccines
Accesso online:	https://doi.org/10.1038/s41541-026-01468-y
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