Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing.

Miltefosine (MF) is the first oral compound used in the chemotherapy against leishmaniasis. Since the mechanism of action of this drug and the targets of MF in Leishmania are unclear, we generated in a step-by-step manner Leishmania major promastigote mutants highly resistant to MF. Two of the mutan...

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Egile Nagusiak:	Adriano C Coelho, Sébastien Boisvert, Angana Mukherjee, Philippe Leprohon, Jacques Corbeil, Marc Ouellette
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Public Library of Science (PLoS) 2012-01-01
Saila:	PLoS Neglected Tropical Diseases
Sarrera elektronikoa:	http://europepmc.org/articles/PMC3279362?pdf=render
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