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Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

ABSTRACT Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation of candidiasis. Epithelial cell invasi...

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Principais autores: Marisa Valentine, Paul Rudolph, Axel Dietschmann, Antzela Tsavou, Selene Mogavero, Sejeong Lee, Emily L. Priest, Gaukhar Zhurgenbayeva, Nadja Jablonowski, Sandra Timme, Christian Eggeling, Stefanie Allert, Edward Dolk, Julian R. Naglik, Marc T. Figge, Mark S. Gresnigt, Bernhard Hube
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2024-03-01
coleção:mBio
Assuntos:
candidalysin
vulvovaginal candidiasis
inflammation
cytotoxicity
therapeutic strategy
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.03409-23
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