Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

ABSTRACT Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation of candidiasis. Epithelial cell invasi...

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Autores principales:	Marisa Valentine, Paul Rudolph, Axel Dietschmann, Antzela Tsavou, Selene Mogavero, Sejeong Lee, Emily L. Priest, Gaukhar Zhurgenbayeva, Nadja Jablonowski, Sandra Timme, Christian Eggeling, Stefanie Allert, Edward Dolk, Julian R. Naglik, Marc T. Figge, Mark S. Gresnigt, Bernhard Hube
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2024-03-01
Colección:	mBio
Materias:	candidalysin vulvovaginal candidiasis inflammation cytotoxicity therapeutic strategy
Acceso en línea:	https://journals.asm.org/doi/10.1128/mbio.03409-23
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