Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models

Sephin1, an UPR pathway modulator, mitigates TDP-43 cytoplasmic localization and toxicity in ALS motor neurons, improving their survival and showing potential as a therapeutic for ALS. A pathological hallmark of ALS is the abnormal accumulation of misfolded proteins (e.g., TDP-43) and enlarged endop...

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Detalhes bibliográficos

Principais autores:	Emmanuelle Abgueguen, Massimo Tortarolo, Laura Rouviere, Stefania Marcuzzo, Laura Camporeale, Alexandre Henriques, Laura Pasetto, Georgia R Culley, Valentina Bonetto, Anca Marian, Beatrice L Lejeune, Anne Visbecq, Giuseppe Lauria, Edor Kabashi, Noëlle Callizot, Caterina Bendotti, Pierre Y Miniou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Life Science Alliance LLC 2025-09-01
coleção:	Life Science Alliance
Acesso em linha:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202403195
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