Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models
Sephin1, an UPR pathway modulator, mitigates TDP-43 cytoplasmic localization and toxicity in ALS motor neurons, improving their survival and showing potential as a therapeutic for ALS. A pathological hallmark of ALS is the abnormal accumulation of misfolded proteins (e.g., TDP-43) and enlarged endop...
I tiakina i:
| Ngā kaituhi matua: | , , , , , , , , , , , , , , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
Life Science Alliance LLC
2025-09-01
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| Rangatū: | Life Science Alliance |
| Urunga tuihono: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202403195 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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