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DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents

Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class of therapeutic agents. The targeting of cytotoxic payloads via the specificity and selectivity of the antibody has led to substantial clinical...

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Principais autores: Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Peter J. Hudson, Gregory P. Adams, Glen C. MacDonald, Jeannick Cizeau
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2016-12-01
Series:Molecules
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Acceso en liña:http://www.mdpi.com/1420-3049/21/12/1741
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