Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells.

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

Descripción completa

Detalles Bibliográficos

Autores principales:	James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kumar
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2012-01-01
Colección:	PLoS ONE
Acceso en línea:	http://europepmc.org/articles/PMC3511409?pdf=render
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!