Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion

Lipid emulsion (LE) therapy has been used to reduce overdose of bupivacaine (BPV)-induced cardiotoxicity. The TWIK-related potassium channel-1 (TREK-1) is inhibited by BPV and activated by polyunsaturated fatty acids, which are the main component in LE. These pharmacological properties inspired us t...

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Bibliographic Details

Main Authors:	Jun Ho Yang, Adrian S. Siregar, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Jaehee Han, Ju-Tae Sohn, Jong Woo Kim, Dawon Kang
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2019-05-01
Series:	Cells
Subjects:	bupivacaine cardiomyoblast lipid emulsion membrane potential TREK-1
Online Access:	https://www.mdpi.com/2073-4409/8/5/454
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