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Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion

Lipid emulsion (LE) therapy has been used to reduce overdose of bupivacaine (BPV)-induced cardiotoxicity. The TWIK-related potassium channel-1 (TREK-1) is inhibited by BPV and activated by polyunsaturated fatty acids, which are the main component in LE. These pharmacological properties inspired us t...

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Principais autores: Jun Ho Yang, Adrian S. Siregar, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Jaehee Han, Ju-Tae Sohn, Jong Woo Kim, Dawon Kang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-05-01
coleção:Cells
Assuntos:
bupivacaine
cardiomyoblast
lipid emulsion
membrane potential
TREK-1
Acesso em linha:https://www.mdpi.com/2073-4409/8/5/454
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