Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier

Abstract Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier. Recently, we demonstrated that K2P channels, TWIK-related K+ channel-1 (TREK-1), and TWIK-related arachidonic acid-activated K + channel (TRAAK),...

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Autores principales:	Hirosato Kanda, Koichi Noguchi, Yi Dai
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-01-01
Colección:	Molecular Brain
Materias:	Node of Ranvier Two-pore-domain potassium channels Membrane stretch Action potential Single-channel activity
Acceso en línea:	https://doi.org/10.1186/s13041-023-01000-6
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