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RSPO1, a potent inducer of pancreatic β cell neogenesis

Summary: Inducing the neogenesis of pancreatic insulin-producing β cells holds great promise for diabetes research. However, non-toxic compounds with such activities remain to be discovered. Herein, we report the identification of RSPO1, a key agonist of the Wnt/β-catenin pathway, as an inducer of β...

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Tallennettuna:
Päätekijät: Serena Silvano, Tiziana Napolitano, Magali Plaisant, Anette Sousa-De-Veiga, Hugo Fofo, Chaïma Ayachi, Benoit Allegrini, Samah Rekima, Estelle Pichery, Jérôme Becam, Valentin Lepage, Caroline Treins, Laura Etasse, Loan Tran, Julien Thévenet, Gianni Pasquetti, Julie Kerr-Conte, François Pattou, Paolo Botti, Arduino Arduini, Jacques Mizrahi, Benjamin Charles, Patrick Collombat
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2025-05-01
Sarja:Cell Reports Medicine
Aiheet:
Rspo1
Wnt/β-catenin signaling
β cell replication
endocrine pancreas
islets of Langerhans
diabetes
Linkit:http://www.sciencedirect.com/science/article/pii/S2666379125001995
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