RSPO1, a potent inducer of pancreatic β cell neogenesis

Summary: Inducing the neogenesis of pancreatic insulin-producing β cells holds great promise for diabetes research. However, non-toxic compounds with such activities remain to be discovered. Herein, we report the identification of RSPO1, a key agonist of the Wnt/β-catenin pathway, as an inducer of β...

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主要な著者:	Serena Silvano, Tiziana Napolitano, Magali Plaisant, Anette Sousa-De-Veiga, Hugo Fofo, Chaïma Ayachi, Benoit Allegrini, Samah Rekima, Estelle Pichery, Jérôme Becam, Valentin Lepage, Caroline Treins, Laura Etasse, Loan Tran, Julien Thévenet, Gianni Pasquetti, Julie Kerr-Conte, François Pattou, Paolo Botti, Arduino Arduini, Jacques Mizrahi, Benjamin Charles, Patrick Collombat
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2025-05-01
シリーズ:	Cell Reports Medicine
主題:	Rspo1 Wnt/β-catenin signaling β cell replication endocrine pancreas islets of Langerhans diabetes
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666379125001995
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