Ion Channel Impairment and Myofilament Ca²⁺ Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy

Life-threatening ventricular arrhythmias are the main clinical burden in patients with hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild structural disease. While massive hypertrophy, fibrosis and microvascular ischemia are the main mechanisms underlying sustained r...

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Bibliographic Details

Main Authors:	Lorenzo Santini, Raffaele Coppini, Elisabetta Cerbai
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2021-10-01
Series:	Cells
Subjects:	HCM ion currents afterdepolarizations excitation-contraction coupling sarcomeres EAD
Online Access:	https://www.mdpi.com/2073-4409/10/10/2789
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