Ion Channel Impairment and Myofilament Ca²⁺ Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy

Life-threatening ventricular arrhythmias are the main clinical burden in patients with hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild structural disease. While massive hypertrophy, fibrosis and microvascular ischemia are the main mechanisms underlying sustained r...

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Detalhes bibliográficos

Principais autores:	Lorenzo Santini, Raffaele Coppini, Elisabetta Cerbai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-10-01
coleção:	Cells
Assuntos:	HCM ion currents afterdepolarizations excitation-contraction coupling sarcomeres EAD
Acesso em linha:	https://www.mdpi.com/2073-4409/10/10/2789
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