Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole

Abstract Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from incomplete inactivation of voltage-gated sodium chan...

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Detalles Bibliográficos

Principais autores:	David Hollingworth, Frances Thomas, Dana A. Page, Mohamed A. Fouda, Raquel Lopez-Rios De Castro, Altin Sula, Vitaliy B. Mykhaylyk, Geoff Kelly, Martin B. Ulmschneider, Peter C. Ruben, B. A. Wallace
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-09-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-024-52539-4
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