Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole

Abstract Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from incomplete inactivation of voltage-gated sodium chan...

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Xehetasun bibliografikoak

Egile Nagusiak:	David Hollingworth, Frances Thomas, Dana A. Page, Mohamed A. Fouda, Raquel Lopez-Rios De Castro, Altin Sula, Vitaliy B. Mykhaylyk, Geoff Kelly, Martin B. Ulmschneider, Peter C. Ruben, B. A. Wallace
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2024-09-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-024-52539-4
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