Molecular insights into the regulation of GNPTαβ by LYSET
Abstract In vertebrates, newly synthesized lysosomal enzymes traffic to lysosomes through the mannose-6-phosphate (M6P) pathway. The Golgi membrane protein LYSET was recently discovered to regulate lysosome biogenesis by controlling the level of GlcNAc-1-phosphotransferase (GNPT). However, its worki...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2026-03-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-026-70402-6 |
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