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Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity

Messenger RNA (mRNA) has become one of the most potential drugs in recent years. However, efficient and safe delivery of fragile and easily degradable mRNA is a major challenge. Appropriate delivery system (DS) determines the final effect of mRNA. Cationic lipids play a crucial and decisive role in...

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Principais autores: Lin Wang, Huanchun Xing, Shuai Guo, Wenbin Cao, Zinan Zhang, Lijuan Huang, Sui Xin, Yuan Luo, Yongan Wang, Jun Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2023-12-01
coleção:Drug Delivery
Assuntos:
Liposome
mRNA transfection
nanocarrier
lipid nanoparticle
mRNA drug
Acesso em linha:https://www.tandfonline.com/doi/10.1080/10717544.2023.2219869
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