Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to inhibit CA IX in nanomolar range in vitro and red...

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Автори:	Ashok Aspatwar, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Taylor & Francis Group 2018-01-01
Серія:	Journal of Enzyme Inhibition and Medicinal Chemistry
Предмети:	Nitroimidazoles carbonic anhydrase IX zebrafish Xenopus oocytes in vivo inhibition
Онлайн доступ:	http://dx.doi.org/10.1080/14756366.2018.1482285
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