Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against human CA I, CA II and CA IX. We also evaluated t...

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Detalhes bibliográficos

Principais autores:	Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2020-01-01
coleção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	carbonic anhydrases carbonic anhydrase inhibitors synthesis toxicity evaluation lethal concentration zebrafish embryos
Acesso em linha:	http://dx.doi.org/10.1080/14756366.2019.1685510
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