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An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs

BackgroundDirect transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus. Liver cells are an ideal source for generating IPCs because they have regenerative ability and a developmental process simil...

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Principais autores: Shinan Ma, Mengjie Yang, Wenhui Zhou, Longjun Dai, Yan Ding, Xingrong Guo, Yahong Yuan, Junming Tang, Dongsheng Li, Xiaoli Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-06-01
Serier:Frontiers in Genetics
Fag:
transdifferentiation
IVT mRNA
TGIF2
hepatocytes
insulin-producing cells
transcription factors
Online adgang:https://www.frontiersin.org/article/10.3389/fgene.2020.00575/full
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