SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics

Summary: Dilated cardiomyopathy (DCM) is associated with high mortality despite advanced therapies. The LMNA gene encodes lamin A/C and is the second most frequently mutated gene associated with DCM, for which therapeutic options are limited. Here we generated Lmna–/– mice and found they exhibited c...

詳細記述

書誌詳細

主要な著者:	Zunhui Du, MS, Yanting Zhou, MS, Qiheng Li, MS, Yuan Xie, MS, Tingfang Zhu, MS, Jing Qiao, MS, Ruihong Zhang, BS, Yangyang Bao, MD, PhD, Lingjie Wang, MD, PhD, Yinyin Xie, PhD, Jinwei Quan, MS, Menglu Lin, MS, Ning Zhang, MD, PhD, Qi Jin, MD, PhD, Wenbin Liang, MD, PhD, Liqun Wu, MD, PhD, Tong Yin, MD, PhD, Yucai Xie, MD, PhD
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2024-10-01
シリーズ:	JACC: Basic to Translational Science
主題:	dilated cardiomyopathy LMNA mitochondrial bioenergetics proteomics SIRT1
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2452302X24002183
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!