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SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics

Summary: Dilated cardiomyopathy (DCM) is associated with high mortality despite advanced therapies. The LMNA gene encodes lamin A/C and is the second most frequently mutated gene associated with DCM, for which therapeutic options are limited. Here we generated Lmna–/– mice and found they exhibited c...

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Autores principales: Zunhui Du, MS, Yanting Zhou, MS, Qiheng Li, MS, Yuan Xie, MS, Tingfang Zhu, MS, Jing Qiao, MS, Ruihong Zhang, BS, Yangyang Bao, MD, PhD, Lingjie Wang, MD, PhD, Yinyin Xie, PhD, Jinwei Quan, MS, Menglu Lin, MS, Ning Zhang, MD, PhD, Qi Jin, MD, PhD, Wenbin Liang, MD, PhD, Liqun Wu, MD, PhD, Tong Yin, MD, PhD, Yucai Xie, MD, PhD
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2024-10-01
Colección:JACC: Basic to Translational Science
Materias:
dilated cardiomyopathy
LMNA
mitochondrial bioenergetics
proteomics
SIRT1
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2452302X24002183
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