The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis

T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts. We retrospectively genotyped HLA-DPB1 in 3523 patie...

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Auteurs principaux:	Daphne Mytilineos, Chrysanthi Tsamadou, Christine Neuchel, Uwe Platzbecker, Donald Bunjes, Natalie Schub, Eva Wagner-Drouet, Gerald Wulf, Nicolaus Kröger, Niels Murawski, Hermann Einsele, Kerstin Schaefer-Eckart, Sebastian Freitag, Jochen Casper, Martin Kaufmann, Mareike Dürholt, Bernd Hertenstein, Stefan Klein, Mark Ringhoffer, Carlheinz R. Mueller, Sandra Frank, Hubert Schrezenmeier, Daniel Fuerst, Joannis Mytilineos
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2021-01-01
Collection:	Frontiers in Immunology
Sujets:	stem cell transplantation graft-versus-host-disease HLA-DPB1 HLA-DPB1 expression HLA-DPB1-permissiveness
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.614976/full
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