HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation

The HLA-DRB3/4/5 loci are closely linked to the HLA-DRB1 gene. Mismatches in these loci occur with a frequency of about 8%–12% in otherwise 10/10 HLA-matched transplant pairs. There is preliminary evidence that these disparities may associate with increased acute graft-versus-host disease (GvHD) rat...

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Κύριοι συγγραφείς:	Chrysanthi Tsamadou, Daphne Engelhardt, Uwe Platzbecker, Elisa Sala, Thomas Valerius, Eva Wagner-Drouet, Gerald Wulf, Nicolaus Kröger, Niels Murawski, Hermann Einsele, Kerstin Schaefer-Eckart, Sebastian Freitag, Jochen Casper, Martin Kaufmann, Mareike Dürholt, Bernd Hertenstein, Stefan Klein, Mark Ringhoffer, Sandra Frank, Christine Neuchel, Hubert Schrezenmeier, Joannis Mytilineos, Daniel Fuerst
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-12-01
Σειρά:	Frontiers in Immunology
Θέματα:	HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DRB3/4/5 unrelated hematopoietic stem cell transplantation (uHSCT) HLA-matched
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.771449/full
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